Neuroengineering focuses on translation of our knowledge of the brain into practical solutions for therapeutic intervention as well as fundamental expansion of knowledge of brain function through studies of basic brain mechanisms of metabolism and function. A large number of neuroscience faculty at the University of Minnesota span the interface between basic Neuroscience and translation to treatments. This includes faculty who work on the development of brain-machine interfaces.

Research areas focus on: development of neural prostheses for hearing loss; neuromodulation approaches such as deep brain stimulation; computational modeling of how populations of neurons work in producing complex behaviors, decision making, learning and memory, and cognition; calcium imaging to understand the neuropathology in diseases like epilepsy; neural basis of spatial cognition and working memory and dysfunction in psychiatric diseases;  fMRI and other imaging approaches to understand both normal and diseased brain function; optical imaging of the brain to understand control of movement; mechanisms that control visually guided behaviors; and dynamics of neural ensemble activity during learning.