David Linden

Ph.D. 1999

Thesis Title:

The Role of Spinal Neurokinin 3 Receptors in Processing Nociceptin Information

Current Position:

Assistant Professor of Physiology, College of Medicine, Mayo Clinic School of Medicine

Associate Consultant, Department of Physiology & Biomedical Engineering
Mayo Clinic, Rochester, Minnesota

Major Advisor(s):

Virginia Seybold, Ph.D.

Selected Publications:

  • Jia YP, Linden DR, Serie JR, Seybold VS. Nociceptin/orphanin FQ binding increases in superficial laminae of the rat spinal cord during persistent peripheral inflammation. Neurosci Lett. 1998; 250:21-4. PMID:9696056.
  • Linden DR, Jia YP, Seybold VS. Spinal neurokinin3 receptors facilitate the nociceptive flexor reflex via a pathway involving nitric oxide. Pain. 1999; 80:301-8. PMID:10204743.
  • Linden DR, Seybold VS. Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide. Pain. 1999; 80:309-17. PMID:10204744.
  • Linden DR, Chell MJ, El-Fakahany EE, Seybold VS. Neurokinin3 receptors couple to the activation of neuronal nitric oxide synthase in stably transfected Chinese hamster ovary cells. J Pharmacol Exp Ther. 2000; 293:559-68. PMID:10773029.
  • Linden DR, Reutter MA, McCarson KE, Seybold VS. Time-dependent changes in neurokinin3 receptors and tachykinins during adjuvant-induced peripheral inflammation. Neuroscience. 2000; 98:801-11. PMID:10891623.
  • Linden DR, Manning BP, Bunnett NW, Mawe GM. Agonists of proteinase activated receptor 2 (PAR2) excite guinea pig ileal myenteric neurons. Eur J Clin Pharmacol. 2001; 431:311-4.
  • Linden DR, El-Fakahany EE. Microglial derived nitric oxide decreases serotonin content in rat basophilic leukemia (RBL-2H3) cells. Eur J Clin Pharmacol. 2002; 436:53-6.
  • Linden DR, El-Fakahany EE. Arachidonic acid inhibition of muscarinic receptor-mediated nitric oxide production occurs at the level of calcium mobilization in Chinese hamster ovary cells. Neurochem Res. 2002; 27:441-9. PMID:12199147.
  • Linden DR, Chen JX, Gershon MD, Sharkey KA, Mawe GM. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2003; 285:G207-16. PMID:12646422.
  • Linden DR, Sharkey KA, Mawe GM. Enhanced neuronal excitability in the myenteric plexus of the inflamed guinea pig distal colon. J Physiol. 2003; 547:589-601. PMID:12562910. PMCID:2342639.

Honors and Awards:

  • Bacaner Award
David Linden