Jerrold Vitek, MD, Ph.D.

Professor and Chair, Department of Neurology

E-MAIL: vitek004@umn.edu

Research Interests:

Understanding the pathophysiological basis for the development of Parkinson's disease and dystonia, exploring the mechanisms underlying the therapeutic effect of DBS, clinical trials examining the effect of DBS for the treatment of neurological and psychiatric disease, and exploring new applications and brain targets for DBS for neurological and psychiatric disorders.


Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Doval A, Murali A, Jensen A, Baker K, Vitek JL. Information in Pallidal Neurons Increases with Parkinsonian Severity. Parkinsonism Relat Disord. 2015 Nov; 21(11):1355-61.

Connolly A, Vetter R, Hetke J, Teplitzky B, Kipke D, Pellinene D, Anderson D, Baker K, Vitek J, Johnson M. A Novel Lead Design for Modulation and Sensing of Deep Brain Structures. IEEE Trans Biomed Eng. 28 Oct 2015 [Epub ahead of print]

Connolly AT, Muralidharan A, Hendrix C, Gupta R, Stanslaski S, Denison T, Baker KB, Vitek JL, and Johnson MD. Local field potential recordings in a non-human primate model of Parkinson's disease using the Activa® PC+S. Journal of Neural Engineering. J Neural Eng. 15 October 2015; 12 (6):066012 [Epub ahead of print]

Agnesi F, Muralidharan A, Baker KB, Vitek JL, Johnson MD. Fidelity of frequency and phase entrainment of circuit-level spike activity during DBS. J Neurophysiol. 2015 Aug;114(2):825-34.

Zitella LM, Teplitzky BA, Yager P, Hudson HM, Brintz K, Duchin Y, Harel N, Vitek JL, Baker KB, Johnson MD. Subject-specific computational modeling of DBS in the PPTg area. Front Comput Neurosci. 2015 Jul 14;9:93.

Connolly AT, Jensen AL, Baker KB, Vitek JL, Johnson MD. Classification of pallidal oscillations with increasing parkinsonian severity. J Neurophysiol. 2015 Jul;114(1):209-18.

Zitella LM, Xiao Y, Teplitzky BA, Kastl DJ, Duchin Y, Baker KB, Vitek JL, Adriany G, Yacoub E, Harel N, Johnson MD. In Vivo 7T MRI of the Non-Human Primate Brainstem. PLoS One. 2015 May 12;10(5):e0127049.

Connolly AT, Jensen AL, Bello EM, Netoff TI, Baker KB, Johnson MD, Vitek JL. Modulations in oscillatory frequency and coupling in globus pallidus with increasing parkinsonian severity. J Neurosci. 2015 Apr 15;35(15):6231-40.

Pulliam CL, Heldman DA, Orcutt TH, Mera TO, Giuffrida JP, Vitek JL. Motion sensor strategies for automated optimization of deep brain stimulation in Parkinson's disease. Parkinsonism Relat Disord. 2015 Apr;21(4):378-82.

Johnson LA, Xu W, Baker KB, Zhang J, Vitek JL. Modulation of motor cortex neuronal activity and motor behavior during subthalamic nucleus stimulation in the normal primate. J Neurophysiol. 2015 Feb 11;:jn.00997.2014.

Volkmann J, Mueller J, Deuschl G, Kühn AA, Krauss JK, Poewe W, Timmermann L, Falk D, Kupsch A, Kivi A, Schneider GH, Schnitzler A, Südmeyer M, Voges J, Wolters A, Wittstock M, Müller JU, Hering S, Eisner W, Vesper J, Prokop T, Pinsker M, Schrader C, Kloss M, Kiening K, Boetzel K, Mehrkens J, Skogseid IM, Ramm-Pettersen J, Kemmler G, Bhatia KP, Vitek JL, Benecke R; DBS study group for dystonia. Pallidal neurostimulation in patients with medication-refractory cervical dystonia: a randomised, sham-controlled trial. Lancet Neurol. 2014 Sep;13(9):875-84.

Agnesi F, Connolly AT, Baker KB, Vitek JL, Johnson MD. Deep brain stimulation imposes complex informational lesions. PLoS One. 2013 Aug 26;8(8):e74462.

Johnson MD, Lim HH, Netoff TI, Connolly AT, Johnson N, Roy A, Holt A, Lim KO, Carey JR, Vitek JL, He B. Neuromodulation for brain disorders: challenges and opportunities. IEEE Trans Biomed Eng. 2013 Mar;60(3):610-24.

Agnesi F, Johnson MD, Vitek JL. Deep brain stimulation: how does it work? Handb Clin Neurol. 2013;116:39-54.

Hendrix CM, Vitek JL. Toward a network model of dystonia. Ann N Y Acad Sci. 2012 Aug;1265:46-55.

Johnson MD, Zhang J, Ghosh D, McIntyre CC, Vitek JL. Neural targets for relieving parkinsonian rigidity and bradykinesia with pallidal deep brain stimulation. J Neurophysiol. 2012 Jul;108(2):567-77.

Vitek JL. Long-term benefit from deep brain stimulation of the subthalamic nucleus: is it for everyone? Alzheimers Res Ther. 2012 May 9;4(3):13.

Vitek JL, Zhang J, Hashimoto T, Russo GS, Baker KB. External pallidal stimulation improves parkinsonian motor signs and modulates neuronal activity throughout the basal ganglia thalamic network. Exp Neurol. 2012 Jan;233(1):581-6.

Zhang J, Wang ZI, Baker KB, Vitek JL. Effect of globus pallidus internus stimulation on neuronal activity in the pedunculopontine tegmental nucleus in the primate model of Parkinson's disease. Exp Neurol. 2011 Jul 29.

Baker KB, Zhang J, Vitek JL. Pallidal stimulation: effect of pattern and rate on bradykinesia in the non-human primate model of Parkinson's disease. Exp Neurol. 2011 Oct;231(2):309-13. Epub 2011 Jul 1.

Deogaonkar M, Wilson K, Vitek J. Amantadine induced reversible corneal edema. J Clin Neurosci . 2011 Feb;18(2):298-9.

Marks WJ Jr, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K, Kordower JH, Olanow CW. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol . 2010 Dec;9(12):1164-72.

Bronstein JM, Tagliati M, Alterman RL, Lozano AM, Volkmann J, Stefani A, Horak FB, Okun MS, Foote KD, Krack P, Pahwa R, Henderson JM, Hariz MI, Bakay RA, Rezai A, Marks WJ Jr, Moro E, Vitek JL, Weaver FM, Gross RE, Delong MR. Deep Brain Stimulation for Parkinson Disease: An Expert Consensus and Review of Key Issues. Arch Neurol . 2010 Oct 11.

Alberts JL, Hallahan K, Thota A, Noecker AM, Vitek JL, McIntyre CC. Reducing cognitive-motor declines associated with bilateral subthalamic deep brain stimulation through computational modelling in a Parkinson's disease patient. J Neurol Neurosurg Psychiatry . 2010 Oct;81(10):1170-2.

Jerrold Vitek