Laura Stone

Ph.D. 1999

Thesis Title:

Alpha-2 Adrenergic Receptor Subtypes in Pain and Analgesia

Current Position:

Associate Professor
Faculty of Dentistry, Alan Edwards Centre for Research on Pain
McGill University Montreal, Quebec, Canada

Major Advisor(s):

Selected Publications:

  • Schuster DJ, Kitto KF, Overland AC, Messing RO, Stone LS, Fairbanks CA, Wilcox GL. Protein kinase Cε is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs. J Neurosci. 2013 Aug 14;33(33):13538-46.
  • M. Millecamps, M. Tajerian, L. Naso, L.S Stone; Lumbar Intervertebral Disc Degeneration Associated with Axial and Radicular Low Back Pain in Aging SPARC-null Mice; Pain, 2012; 153(6):1167-79. http://www.ncbi.nlm.nih.gov/pubmed/22414871
  • M. Tajerian, M. Millecamps, L.S Stone; Morphine and Clonidine Synergize to Ameliorate Low Back Pain in Mice; Pain Research and Treatment, Volume 2012, Article ID150842. http://www.ncbi.nlm.nih.gov/pubmed/22414871
  • N. Audet, O. Mnie-Filali, M. Amraei, A-J. Chabot-Doré, M. Millecamps, L.S. Stone and G. Pineyro; Differential Association of Receptor-Gβγ Complexes with β-arrestin2 Determines Recycling Bias and Potential for Tolerance of Delta Opioid Receptor (DOR) Agonists; J Neuroscience, 32(14):4827– 4840, 2012.
  • M. Tajerian, S. Alvarado, M. Millecamps, T. Dashwood, K.M. Anderson, L. Haglund, J.A. Ouellet, M. Szyf, L.S Stone; DNA Methylation of SPARC is Associated with Low Back Pain; Molecular Pain, 7(1):65, 2011.
  • D.A. Seminowicz, T.H. Wideman, L. Naso, Z. Hatami-Khoroushahi, S. Fallatah, M. Ware, P. Jarzem, M.C. Bushnell, Y Shir, J.A. Ouellet, and L.S. Stone; Effective Treatment of Chronic Low Back Pain Reverses Structural and Functional Brain Changes; Journal of Neuroscience, 31(20):7540-7550, 2011.
  • F.J. Symons, J.J. Wolff, L.S. Stone, T. Lim and J.W. Bodfish; Salivary Biomarkers of HPA Axis and Autonomic Activity in Adults with Intellectual Disability With and Without Stereotyped and Self-Injurious Behavior Disorders; Journal of Neurodevelopmental Disorders: 3(2):144-151, 2011.
  • M. Millecamps, M. Tajarian, E.H. Sage, and L.S. Stone; Behavioral Signs of Chronic Back Pain in the SPARC-null mouse; Spine, 36(2):95-102, 2011 (NIHMS221485, CAPMC1525).
  • A.C. Overland, K.F. Kitto, A.J. Chabot-Dore, P.E. Rothwell, C.A. Fairbanks, L.S. Stone, G.L. Wilcox. 2009. Protein Kinase C Mediates the Synergistic Interaction Between Agonists Acting at Alpha-2-Adrenergic and Delta-Opioid Receptors in Spinal Cord. Journal of Neuroscience, 29(42):13264-13273, 2009.
  • M.S. Riedl, S. Schnell, A.C. Overland, A-J. Chabot-Dore, A.M. Taylor, A. Ribeiro-Da-Silva, R. Elde, G.L. Wilcox and L.S. Stone. 2009. Co-expression of Alpha-2a-adrenergic and delta-opioid receptors in Substance P terminals in rat dorsal horn. Journal of Comparative Neurology 513(4):385-398; 2009 (NIHMS89435).
  • C.A. Fairbanks, K.F. Kitto, H.O. Nguyen, L.S. Stone, and G.L. Wilcox. 2009. Clonidine and Dexmedetomidine Produce Antinociceptive Synergy in Mouse Spinal Cord. Anesthesiology 110(3):638-47; 2009.

Honors and Awards:

Laura Stone