Amelioration of Ischemic Brain Injury with Human Umbilical Cord Blood Stem Cells: Mechanisms of Action
Post Doctoral, Department of Surgery, University of Minnesota
Undergraduate Institution and Major/Degree:
St. Olaf College, B.A. Biology, Neuroscience concentration 2007
My research focuses on investigating the potential of adult stem cells – namely non-hematopoetic umbilical cord blood derived stem cells – as a treatment for ischemic stroke. These cells not only have the potential to reduce stroke injury, but also to ameliorate the injury caused by stroke at a later time point than any other currently available stroke treatments. A second focus of my research is the characterization of changes that occur with aging that correspond to, or may act as predictors of, poor outcome following ischemic stroke. I am currently in the process of validating the use of nuclear magnetic resonance (NMR) metabolomics to identify changes in the metabolome profile before and after ischemic stroke in the rat, as well as comparing metabolite changes between serum and brain tissue in the rat following stroke.
- Al Beitz
- Matt Chafee
- Walter Low
Courses Taken Beyond the Core Courses:
- NSU 5667 - Neurobiology in Disease
- CMB 8335 - Molecular Biology Techniques
- GERO 5105 - Multidisciplinary Perspectives on Aging
- GERO 5110 - Biology of Aging
- GERO 8020 - Gerontology Seminar
- GERO 5101 - Milestones in the Biology of Aging
Graduate Level Minor:
Conferences Attended and Presentations:
- Society for Neuroscience Annual Meeting, 2007
- American Heart Association Stroke Conference, 2010
- Gordon-Kenan Research Seminar: Oxidative Stress and Disease, March 2011
- Gordon-Kenan Research Seminar: Common Threads in Oxidative Stress and Disease, March 2011
- International Neural Therapy and Repair Meeting: May 2011
- American Society for Neural Therapy and Repair Meeting: April 2012
- Alvin Beitz - Chair
- Walter Low - Advisor
- Jan Dubinsky
- LaDora Thompson
- In preparation: Hocum Stone, Laura L, Xiao, Feng; Rotschafer, Jessica; Juliano, Mairo; Sanberg, Cyndy; Sanberg, Paul B.; Kuzmin-Nichols, Nicole; Grande, Andrew; Cheeran, Maxim; Low, Walter C. (2014). Amelioration of Ischemic Brain Injury in Rats with Human Umbilical Cord Blood Stem Cells: Mechanisms of Action.
- In press: Christopher T. Holley, Eric K. Long, Tammy A. Butterick, Cayla M. Duffy, Megan E. Lindsey, Laura Hocum Stone, Edward O. McFalls, and Rosemary F. Kelly. (2014). Mitochondrial Fusion Proteins in Revascularized Hibernating Hearts. Journal of Surgical Research
- Schuster DJ, Kitto KF, Overland AC, Messing RO, Stone LS, Fairbanks CA, Wilcox GL. Protein kinase Cε is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs. J Neurosci. 2013 Aug 14;33(33):13538-46.
- Stone, Laura L; Low, Walter C.; Grande, Andrew. (2013). Stem Cell Therapies for Ischemic Stroke. In L. Lescaudron; J. Rossignol; GL Dunbar; R. Primlani (Eds). Stem Cells in Neurological Diseases. Enfield, NH, USA. SCIENCE PUBLISHERS, an imprint of Edenbridge Ltd. In Press.
- Misra, Vivek; Ritchie, Michael M.; Stone, L.; Low, Walter; Janardhan, Vallabh. (2011). Stem cell therapy in ischemic stroke: Role of intra-venous and intra-arterial therapy. Neurology.79(13).
- Wyckhuys K.A.G., Stone L., Desneux N., Hoelmer K.A., Hopper K.R., Heimpel G.E. (2008). Parasitism of the soybean aphid, Aphis glycines by Binodoxys communis: the role of aphid defensive behavior and parasitoid reproductive performance. Bulletin of Entomological Research, 1-10.
- Stone, L.L. (2012). “Intra-Venous Administration of High and Low Passaged Non-Hematopoietic Human Umbilical Cord Blood Stem Cells (nh-UCBSC) as a Novel Therapy for Ischemic Stroke”. Invited speaker at the American Society of Neural Therapy and Repair Annual Meeting, April 2012.
- Stone, L.L. (2011). “Identification of serum biomarkers of ischemic stroke using 1H-NMR spectroscopy”. Invited speaker at the Aging and Neurobiology of Disease Spring Symposium at the University of Minnesota. April, 2011.
- Stone, L.L. (2011). “Identification of serum biomarkers of ischemic stroke using 1H-NMR spectroscopy”. Invited speaker at the Gordon-Kenan Research Seminar on Oxidative Stress and Disease, March 2011.
- Stone, L.L. (2011). “Identification of serum biomarkers of ischemic stroke using 1H-NMR spectroscopy”. Graduate Program in Neuroscience Colloquium, Spring 2011.
- Stone, L.L. (2010). “NMR Spectroscopy and Ischemic Stroke”. Graduate
Program in Neuroscience Colloquium. Spring 2010.
Awards and Honors
- NIH Pharmaco-Neuro Immunology Training Grant, Trainee Summer 2013-2014
- Student Travel Award for the American Society of Neural Therapy and
Repair Annual Meeting, 2012.
- The Stark Award for Advanced Scholarship, 2011.
- NIH Functional Proteomics of Aging Training Grant, 2009 to 2011.
- St. Paul, MN