Marija Cvetanovic, Ph.D.

Assistant Professor, Neuroscience

E-MAIL: mcvetano@umn.edu


Research Interests:

Our lab aims to understand how different brain cells and their interactions influence the onset and progression of neurodegenerative diseases. The ultimate goal is to increase knowledge of these disorders and open new avenues for therapeutic approaches. Another main focus of the lab is to train the next generations of scientists. We will create the supportive environment that is conductive to learning, creating and testing new ideas.


Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Asher M, Johnson A, Zecevic B, Pease D, Cvetanovic M. Ataxin-1 regulates proliferation of hippocampal neural precursors. Neuroscience. 2016 Feb 11;322:54-65. [Epub ahead of print]

Cvetanovic M, Ingram M, Orr H, Opal P. Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1. Neuroscience. 2015 Mar 19;289:289-99.

Cvetanovic M. Decreased expression of glutamate transporter GLAST in bergmann glia is associated with the loss of Purkinje neurons in the spinocerebellar ataxia type 1.Cerebellum. 2015 Feb;14(1):8-11.

Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014 Jul 15;23(14):3733-45.

Cvetanovic M, Kular RK, Opal P. 2012. LANP, an inhibitor of histone acetyl transferase (INHAT) plays a role in Spinocerebellar ataxia 1. Neurobiol Dis. 48(3):526-32.

Cvetanovic M. Patel J, Kini A, Hugo V, Opal P. 2011. VEGF ameliorates the ataxic phenotype in spinocerebellar ataxia 1 (SCA1) mice” Nature Medicine 17: 1445-1447.

Kular RK, Cvetanovic M, Siferd S, Kini AR, Opal P. 2009. Neuronal differentiation is regulated by LANP, a member of the INHAT complex. J Biol Chem. 284 (12):7783-92.

Cvetanovic, M., Rooney, R.J., Garcia, J.J., Toporovskaya, N., Zoghbi, H.Y., and Opal, P. 2007 The role of LANP and ataxin-1 in E4F-mediated transcriptional repression.  EMBO Reports, 8: 671-677.

Patel VA, Longacre-Antoni A, Cvetanovic M, Lee DJ, Feng L, Fan H, Rauch J, Ucker DS, Levine JS.2007 The affirmative response of the innate immune system to apoptotic cells. Autoimmunity. 40(4):274-80.

Cvetanovic M, Mitchell JE, Patel V, Avner BS, Su Y, van der Saag PT, Witte PL, Fiore S, Levine JS, Ucker DS.2006. Specific recognition of apoptotic cells reveals a ubiquitous and unconventional innate immunity. J.Bio.Chem. 281(29):2005-2006

Mitchell JE*, Cvetanovic M*, Tibrewal N, Patel V, Colamonici O, Li M, Flavell RA, Levine JS, Birge RB, Ucker DS.2006 The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells. J.Bio.Chem.281:5718-5725. * equal contribution

Cvetanovic M, Ucker DS. 2004. Innate immune discrimination of apoptotic cells: repression of proinflammatory macrophage transcription is coupled directly to specific recognition. J Immunol. 172(2): 880-9

Chang, S. H., M. Cvetanovic, K. J. Harvey, A. Komoriya, B. Z. Packard, and D. S. Ucker. 2002. The effector phase of physiological cell death relies exclusively on the post-translational activation of resident components. Exp. Cell Res. 277:15-30