Meredith Noetzel

Ph.D. 2009

Thesis Title:

The action of xanomeline on human muscarinic receptors expressed in Chinese
hamster ovary cells

Current Position:

Quality and Regulatory Scientist, Insight Genetics Inc

Undergraduate Institution and Major/Degree:

University of Minnesota-Morris, BA, Biology and Chemistry, 2003

Major Advisor(s):

Esam El-Fakahany, Ph.D.

Lab Rotations:

  • Esam El-Fakahany
  • Walter Low
  • Laura Ranum

Courses Taken Beyond the Core Courses:

  • MICAB 8001 Integrated topics in microbiology, immunology and cancer biology
  • PHCL 5110 Introduction to pharmacology
  • PHCL 5111 - Pharmacogenomics
  • PHCL 8110 - Advanced Pharmacology
  • NSC 8221 - Neurobiology of pain
  • GRAD 8200 - Teaching & Learning in Higher Ed ucation – Beyond the Academy: Practical Job Search Strategies for Ph.D.s
  • OBIO 8022 - Oral Neuroscience
  • OBIO 8030 - Oral Biology Seminar

Graduate Level Minor:

  • Supporting program with an emphasis on pharmacology

Conferences Attended and Presentations:

  • Society for Neuroscience annual meeting - Fall 2004, 2005, 2006, 2007

Committee Members:

  • Bill Engeland (chair)
  • Ginger Seybold
  • Ping Law
  • Esam El-Fakahany (advisor)

Awards and Honors:

  • Biomedical Engineering Institute Fellowship 2005-06
  • National Institutes of Health – Minnesota Craniofacial Research Training Program Fellowship (2006 to present)

Publications:

  • Rook*, J.M., M.J. Noetzel*, W.A. Pouliot, T.M. Bridges, P.N. Vinson, H.P. Cho, Y.Z., R.D. Gogliotti, J.T. Manka, K.J. Gregory, S.R. Stauffer, F.E. Dudek, Z. Xiang, C.M. Niswender, J.S. Daniels, C.K. Jones, C.W. Lindsley, and P.J. Conn (2012)  Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity. (Accepted, Biological Psychiatry). *Authors contributed equally to this work
  • Gregory, K.J.,  M.J. Noetzel, J.M. Rook, P.N. Vinson,  S.R. Stauffer, A.L. Rodriguez, K. Emmitte, C.W. Lindsley, C.M. Niswender and P.J. Conn. (2012). Investigating mGlu5 allosteric modulator cooperativity, affinity and agonism: enriching structure-function studies and SAR. (In press, Molecular Pharmacology)
  • Manka, J., Y. Zhou, A. Chun, E.S. Dawson, P.N. Vinson, C.M. Niswender, M.J. Noetzel, J.M. Rook, T.M. Bridges, J.S. Daniels, P.J. Conn, C.W. Lindsley and S.R. Stauffer.  (2012). Identification of a selective allosteric agonist of mGlu5. Molecular Libraries Probe Report.
  • Digby G.J., M.J. Noetzel, M. Bubser, T.J. Utley, A.G. Walker, N.B. Byun, E.P. Lebois, Z. Xiang, D.J. Sheffler, H.C. Plumley, A.A. Davis, N.E. Nemirovsky, S.E. Mennenga, B.W. Camp, H.A. Bimonte-Nelson, J. Bode, K. Italiano, R. Morrison, S. Daniels, C.M. Niswender, M.F. Olive, C.W. Lindsley, C.K. Jones, and P.J. Conn. (2012) Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animals models. J Neurosci. 20: 8532-8544.
  • Melancon, B.J., A.P. Lamers, T.M. Bridges, G.A. Sulikowski, T.J. Utley, D.J. Sheffler, M.J. Noetzel, R.D. Morrison,, J.S. Daniels, C.M. Niswender, C.K. Jones, P.J. Conn, C.W. Lindsley, M.R. Wood. (2012) Development of a more highly selective M1 antagonist from the continued optimization of the MLPCN probe ML012. Bioorganic and Medicinal Chemistry Letters. 22: 1044-1048.
  • Noetzel, M.J., J.M. Rook, P.N. Vinson, H.P. Cho, E. Days, Y. Zhou, A.L. Rodriguez, H. Laversen, S.R.Stauffer, C.M. Niswender, Z. Xiang, J.S. Daniels, C.W. Lindsley, C.D. Weaver and P.J. Conn.  (2012) Functional impact of allosteric agonist activity of selective positive allosteric modulators of mGlu5 in regulating CNS function. Molecular Pharmacology. 81: 120-133.
  • Grant, M. K. O., M. J. Noetzel, K.C. De Lorme, J. Jakubik, V. Dolezal and E. E. El-Fakahany. (2010)  Pharmacological evaluation of the long-term effects of xanomeline on the M1 muscarinic acetylcholine receptor. PLoS One. 5: e15722. PMID: 21203415
  • Bridges, T.M., J.P. Kennedy, M.J. Noetzel, M.L. Breininger, P.R. Gentry, P.J. Conn, and C.W. Lindsley. (2010) Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead.  Part II: development of a potent and highly selective M1 PAM. Bioorganic and Medicinal Chemistry Letters. 20: 1972-1975
  • Noetzel, M. J., M. K. O. Grant and E. E. El-Fakahany. (2009) Mechanisms of M3 muscarinic receptor regulation by wash-resistant xanomeline binding. Pharmacology. 83: 301-317. PMID: 19401618
  • Noetzel, M., M. K. O. Grant and E. E. El-Fakahany.  Immediate and Delayed Consequences of Xanomeline Wash-Resistant Binding at the M3 Muscarinic Receptor. (2009)  Neurochemical Research. 34: 1138-1149. PMID: 19082883 

Professional Memberships:

  • Society for Neuroscience

Home Town

  • Spring Lake Park , MN
Meredith Noetzel