Roberto Zayas

Ph.D. 2005

Thesis Title:

Calcium Entry and Calcium-Mediated Mechanisms in the Slow-Channel Syndrome

Current Positions:

Associate Director of Entrepreneurship, Faculty Advisor for Mayo Innovation Scholars, and Pre-Law Advisor
Piper Center for Vocationa and Career
St. Olaf College

Founder of Maxscimize

Major Advisor(s):

Christopher M. Gomez

Selected Publications:

  • “Inositol-1,4,5-triphosphate receptors mediate activity-induced subsynaptic Ca2+ signals in muscle fibers and Ca2+ overload in slow-channel syndrome”. Zayas R, Groshong J, Gomez C. In press Journal of Cell Calcium.
  • “Macroscopic properties of spontaneous mutations in SCS: correlation by domain and disease severity”. Zayas R, Gomez C. Synapse. 2006 Jul 31;60(6):441-449.
  • “Apoptotic pathways at muscle fiber synapses are circumscribed, non-lethal, and reversible”. Vohra B, Groshong J, Zayas R, Gomez C. Neurobiology of Disease. 2006 Aug;23(2):462-70.
  • “Acetylcholine receptor mutations in slow-channel syndrome identify an M1 domain allosteric hinge”. Navedo MF, Lasalde-Dominicci JA, Báez-Pagán C, Díaz-Pérez L, Rojas L, Maselli RA., Staub J, Schott K, Zayas R, Gomez CM. Journal of Molecular and Cellular Neuroscience. 2006 May-Jun;32(1-2):82-90.
  • “Novel beta subunit mutation causes a slow-channel syndrome by enhancing activation and decreasing the rate of agonist dissociation.” Navedo MF, Lasalde-Dominicci JA, Baez-Pagan CA, Diaz-Perez L, Rojas LV, Maselli RA, Staub J, Schott K, Zayas R, Gomez CM. Molecular Cellular Neuroscience. 2006 May-Jun;32(1-2):82-90.
  • “Active calcium accumulation underlies severe weakness in a panel of mice with slow-channel syndrome”. Gomez C, Maselli R, Groshong J, Zayas R, Wollmann RL, Cens T, Charnet P. Journal of Neuroscience. 2002 Aug 1; 22(15): 6447-57.
  • “Calpain activation impairs neuromuscular transmission in a mouse model of the slow-channel myasthenic syndrome”. Groshong J, Zayas R, Gomez C. Submitted.
Roberto Zayas