William R. Kennedy, M.D.

Professor, Department of Neurology

E-MAIL: kenne001@umn.edu

Web Page: http://kennedylab.med.umn.edu/


Research Interests:

Medical devices to quantify touch sensation and sweating in diabetic, cancer chemotherapy indudced and other neuropathies.

Immunostaining, confocal microscopy to quantify nerves in skin and gastrointestinal mucosa, epidermal nerve fibers and other nerves in various diseases.


Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Mack MR, Wendelschafer-Crabb G, McAdams BD, Hordinsky MK, Kennedy WR, Tolar J. Peripheral neuro-immune pathology in recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2015 Apr;135(4):1193-7.

Panoutsopoulou IG, Luciano CA, Wendelschafer-Crabb G, Hodges JS, Kennedy WR. Epidermal innervation in healthy children and adolescents. Muscle Nerve. 2015 Mar;51(3):378-84.

de Carvalho Barbosa M, Kosturakis AK, Eng C, Wendelschafer-Crabb G, Kennedy WR, Simone DA, Wang XS, Cleeland CS, Dougherty PM. A quantitative sensory analysis of peripheral neuropathy in colorectal cancer and its exacerbation by oxaliplatin chemotherapy. Cancer Res. 2014 Nov 1;74(21):5955-62.

Loavenbruck A, Wendelschaefer-Crabbe G, Sandroni P, Kennedy WR. Quantification of sweat gland volume and innervation in neuropathy: Correlation with thermoregulatory sweat testing. Muscle Nerve. 2014 Oct;50(4):528-34.

Kosturakis AK, He Z, Li Y, Boyette-Davis JA, Shah N, Thomas SK, Zhang H, Vichaya EG, Wang XS, Wendelschafer-Crabb G, Kennedy WR, Simone DA, Cleeland CS, Dougherty PM. Subclinical peripheral neuropathy in patients with multiple myeloma before chemotherapy is correlated with decreased fingertip innervation density. J Clin Oncol. 2014 Oct 1;32(28):3156-62.

Boyette-Davis JA1, Eng C2, Wang XS3, Cleeland CS3, Weldeschafer-Crabb G4, Kennedy WR, Simone CS5, Zhang H6, and Dougherty PM6* Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. Clinical Cancer Research. In Press. April, 2012.

Waller LA, Särkkä A, Olsbo V, Myllymäki M, Panoutsopoulou IG, Kennedy WR, Wendelschafer-Crabb G. Second-order spatial analysis of epidermal nerve fibers. Stat Med. 2011;30:2827-2841.

Boyette-Davis JA, Cata JP, Zhang H, Driver LC,  Giralt S, Burton AW, Wendelschafer-Crabb G, Kennedy WR, Dougherty, PM. Follow-up psychophysical studies in bortezomib-related chemoneuropathy patients. J Pain. 2011;12:1017-1024.

Kennedy WR, Selim MM, Brink TS, Hodges JS, Wendelschafer-Crabb G, Foster SX, Nolano M, Provitera V, Simone DA. A new device to quantify tactile sensation in neuropathy. Neurology. 2011 May 10;76(19):1642-9.

Azan G, Low WC, Wendelschafer-Crabb G, Ikramuddin S, Kennedy WR. Evidence for neural progenitor cells in the human adult enteric nervous system. Cell Tissue Res. 2011 May;344(2):217-25. Epub 2011 Mar 3.

Lauria G, Hsieh ST, Johansson O, Kennedy WR, Leger JM, Mellgren SI, Nolano M, Merkies ISJ, Polydefkis M, Smith AG, Sommer C, Valls-Solé. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. Joint Task Force of the EFNS and the PNS. J Peripher Nerv Syst. 2010;15:79-92. Review

Lauria G, Hsieh ST, Johansson O, Kennedy WR, Leger JM, Mellgren SI, Nolano M, Merkies ISJ, Polydefkis M, Smith AG, Sommer C, Valls-Solé J. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federations of Neurological Societies and the Peripheral Nerve Society. European Journal of Neurology. 2010;15:79-92. Review

Selim M, Wendelschafer-Crabb G, Redmon JB, Khoruts A, Hodges JS, Koch K, Walk D, Kennedy WR. Gastric mucosal nerve density: a marker of autonomic neuropathy. Neurology 2010;75:973-981. Also see “In Focus review with an image P943.

Selim MM, Wendelschafer-Crabb G, Hodges JS, Simone DA, Foster S, Vanhove GF, Kennedy WR. Variation in quantitative sensory testing and epidermal nerve fiber density in repeated measurements. Pain. 2010; 151:575-581.

Kennedy WR, Vanhove, GF, Tobias J, Bley KR, Walk D, Wendelschafer-Crabb G, Simone DA, Selim M and NGX-4010 C115 Study Group. A Randomized Controlled Open-Label Study of the Long-term Effects of NGX-4010, a High-Concentration Capsaicin Patch, on Epidermal Nerve Fiber Density and Sensory Function in Healthy Volunteers. J Pain. 2010;11:579-87.

Provitera V, Nolano M, Caporaso G, Stancanelli A, Santoro L, Kennedy WR. Evaluation of sudomotor function in diabetes using the dynamic sweat test. Neurology. 2010; 5:74:50-56.

Panoutsopoulou I, Wendelschafer-Crabb G, Kennedy WR. Histological evaluation of neuropathy from analysis of epidermal nerves in a skin blister. Neurology. 2009;72:1205-1210.

Symons FJ, Wendelschafer-Crabb G, Kennedy WR, Heeth W, Bodfish JW. Degranulated mast cells in the skin of adults with self-injurious behavior and neurodevelopmental disorders. Brain, Behavior, and Immunity 2009;23:365–370.

Kennedy WR. In Memorium: Joseph A. Resch MD, FAAN 1914-2009. Neurololgy 2009;73:172.

Symons FJ, Wendelschafer-Crabb G, Kennedy WR, Heeth W, Riddle, JI, Bodfish JW. Degranulated mast cells in the skin of adults with self-injurious behavior and neurodevelopmental disorders. Brain, Behav, and Immun 2009;23:365-370.

Panoutsopoulou I, Wendelschafer-Crabb G, Kennedy WR. Skin Blister: A minimally invasive method to study epidermal nerve fibers (ENFs). Neurology 2009; 72: 1205-1210.


Former Graduate Students:

Nidal Khalili M.D. 1998-1999

Mona Selim M.D., Ph.D. 1999-2000

William R. Kennedy