Mechanisms and Functional Consequences of Glial Signaling in the Retina
Postdoctoral Research Fellow, Neuroscience, University College, London
Undergraduate Institution and Major/Degree:
Iowa State University, BS, Computer Science, 2003
When glial cells are stimulated artificially, they will often initiate a wave of intracellular Ca2+ elevation that spreads to neighboring glia. These calcium waves can modulate synaptic transmission and blood vessel diameter.
We have discovered that glial calcium waves occur spontaneously in the retina, both ex vivo and in vivo. They propagate from cell to cell through ATP release, and they cause constrictions in blood vessels. Spontaneous waves occur more frequently in older animals.
The existence of spontaneous waves validates glial calcium waves as a physiological form of long-range glial communication, and it also implies that glia can be "initiators" of signaling in the brain.
- Eric Newman
- David Redish
- Mark Thomas
Courses Taken Beyond the Core Courses:
- EEB 8990 - Computational Analysis of Biological Networks
- NSC 5201 - Computational Neuroscience
- NSC 5202 - Theoretical Neuroscience
- PHCL 5110 - Introduction to Pharmacology
- PSY 8960 - Synaptic Plasticity in Addiction
Graduate Level Minor:
- Supporting Program
- Society for Neuroscience - Fall 2003, 2004, 2006, 2007, 2008
- Bob Miller (chair)
- Mark Thomas
- Jan Dubinsky
- Eric Newman (advisor)
- Kurth-Nelson Z, Redish AD (2012) Don't let me do that! -- models of precommitment. Frontiers in Neuroscience (in press)
- Kurth-Nelson Z, Bickel WK, Redish AD (2012) A theoretical account of cognitive effects in delay discounting. European Journal of Neuroscience 35:1052.
- van der Meer MA, Kurth-Nelson Z, Redish AD (2012) Information processing in decision-making systems. The Neuroscientist (in press)
- Bickel WK, Christensen DR, Landes RD, Jackson L, Jones BA, Kurth-Nelson Z, Redish AD (2011) Single and cross commodity among cocaine addicts: the commodity and its temporal location determine discounting rate. Psychopharmacology 217:177.
- Kurth-Nelson Z, Redish AD (2010) A reinforcement learning model of precommitment in decision making. Frontiers in Behavioral Neuroscience 4:184.
- Srienc AI, Kurth-Nelson Z, Newman EA (2010) Imaging retinal blood flow with laser speckle flowmetry. Frontiers in Neuroenergetics 2:128.
- Kurth-Nelson Z, Redish AD (2009) Temporal-difference reinforcement learning with distributed representations. PLoS One 4:e7362.
- Kurth-Nelson Z, Mishra A, Newman EA (2009) Spontaneous intercellular calcium waves in retinal glia. Journal of Neuroscience 29:11339.
- Clark BD, Kurth-Nelson Z, Newman EA (2009) Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation. Journal of Neuroscience 29:11237.
- Redish AD, Jensen S, Johnson A, Kurth-Nelson Z (2007) Reconciling reinforcement learning models with behavioral extinction and renewal: implications for addiction, relapse, and problem gambling. Psychological Review 114:784.
Awards and Honors:
- NSF IGERT Fellowship, 2003-2005
- NIH NPCS Fellowship, 2005
- Society for Neuroscienc
- North Branch, Minnesota