Kamil Ugurbil, Ph.D.

Professor, Departments of Biochemistry, Radiology and Medicine

E-MAIL: kamil@cmrr.umn.edu

Research Interests:

The primary focus of the ongoing research activity at the Center for Magnetic Resonance Research (CMRR) is to develop techniques that will permit novel use of high field magnetic resonance (MR) spectroscopy and imaging, and apply these techniques to biomedical questions relevant to basic physiological research and clinical medicine. Among the areas targeted for human MR studies, the most important and prominent is neurophysiology based on non-invasive functional imaging in the brain, high-resolution and/or high contrast imaging of neuroanatomy, imaging of perfusion, and finally spectroscopic studies of metabolism. This laboratory has pioneered the development of non-invasive functional imaging in the human brain using magnetic resonance techniques and endogenous deoxyhemoglobin as an intrinsic contrast agent.

CMRR is equipped with state-of-the-art MR instruments. It has one of the three 4 Tesla systems in the world capable of accommodating humans, and has pioneered high field MR applications with humans. CMRR also housed in March 1993 a first of its kind 9.4 Tesla system which is large enough to work with medium-size animals. In addition, a 4.7 Tesla/40 cm bore system is routinely used for animal studies.


Selected Publications:

(For a comprehensive list of recent publications, refer to PubMed, a service provided by the National Library of Medicine.)

Sotiropoulos SN, Hernández-Fernández M, Vu AT, Andersson JL, Moeller S, Yacoub E, Lenglet C, Ugurbil K, Behrens TE, Jbabdi S. Fusion in diffusion MRI for improved fibre orientation estimation: An application to the 3T and 7T data of the Human Connectome Project. Neuroimage. 2016 Apr 9;134:396-409. [Epub ahead of print]

Schmitter S, Moeller S, Wu X, Auerbach EJ, Metzger GJ, Van de Moortele PF, Uğurbil K. Simultaneous multislice imaging in dynamic cardiac MRI at 7T using parallel transmission. Magn Reson Med. 2016 Mar 7;. [Epub ahead of print]

Ertürk MA, Raaijmakers AJ, Adriany G, Uğurbil K, Metzger GJ. A 16-channel combined loop-dipole transceiver array for 7 Tesla body MRI. Magn Reson Med. 2016 Feb 17;. [Epub ahead of print]

Schmitter S, Schnell S, Uğurbil K, Markl M, Van de Moortele PF. Towards high-resolution 4D flow MRI in the human aorta using kt-GRAPPA and B1+ shimming at 7T. J Magn Reson Imaging. 2016 Feb 3;. [Epub ahead of print]

De Martino F, Moerel M, Ugurbil K, Goebel R, Yacoub E, Formisano E. Frequency preference and attention effects across cortical depths in the human primary auditory cortex. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):16036-41.

Wu X, Zhang X, Tian J, Schmitter S, Hanna B, Strupp J, Pfeuffer J, Hamm M, Wang D, Nistler J, He B, Vaughan TJ, Ugurbil K, de Moortele PF. Comparison of RF body coils for MRI at 3 T: a simulation study using parallel transmission on various anatomical targets. NMR Biomed. 2015 Oct;28(10):1332-44.

Vu AT, Auerbach E, Lenglet C, Moeller S, Sotiropoulos SN, Jbabdi S, Andersson J, Yacoub E, Ugurbil K. High resolution whole brain diffusion imaging at 7T for the Human Connectome Project. Neuroimage. 2015 Aug 7;122:318-331.

Wiesner HM, Balla DZ, Shajan G, Scheffler K, Ugurbil K, Chen W, Uludağ K, Pohmann R. 17 O relaxation times in the rat brain at 16.4 tesla. Magn Reson Med. 2015 Jun 22.

Wu X, Schmitter S, Auerbach EJ, Ugurbil K, Van de Moortele PF. A generalized slab-wise framework for parallel transmit multiband RF pulse design. Magn Reson Med. 2015 May 20.

Hodge MR, Horton W, Brown T, Herrick R, Olsen T, Hileman ME, McKay M, Archie KA, Cler E, Harms MP, Burgess GC, Glasser MF, Elam JS, Curtiss SW, Barch DM, Oostenveld R, Larson-Prior LJ, Ugurbil K, Van Essen DC, Marcus DS. ConnectomeDB-Sharing human brain connectivity data. Neuroimage. 2015 Apr 29. pii: S1053-8119(15)00346-8.

Wang Y, Moeller S, Li X, Vu AT, Krasileva K, Ugurbil K, Yacoub E, Wang DJ. Simultaneous multi-slice Turbo-FLASH imaging with CAIPIRINHA for whole brain distortion-free pseudo-continuous arterial spin labeling at 3 and 7T. Neuroimage. 2015 Mar 30;113:279-288.

Zhu XH, Lu M, Lee BY, Ugurbil K, Chen W. In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2876-81.

Kochunov P, Jahanshad N, Marcus D, Winkler A, Sprooten E, Nichols TE, Wright SN, Hong LE, Patel B, Behrens T, Jbabdi S, Andersson J, Lenglet C, Yacoub E, Moeller S, Auerbach E, Ugurbil K, Sotiropoulos SN, Brouwer RM, Landman B, Lemaitre H, den Braber A, Zwiers MP, Ritchie S, van Hulzen K, Almasy L, Curran J, deZubicaray GI, Duggirala R, Fox P, Martin NG, McMahon KL, Mitchell B, Olvera RL, Peterson C, Starr J, Sussmann J, Wardlaw J, Wright M, Boomsma DI, Kahn R, de Geus EJ, Williamson DE, Hariri A, van 't Ent D, Bastin ME, McIntosh A, Deary IJ, Hulshoff Pol HE, Blangero J, Thompson PM, Glahn DC, Van Essen DC. Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data. Neuroimage. 2015 Mar 4;111:300-311.

Schmitter S, Wu X, Ugurbil K, Van de Moortele PF. Design of parallel transmission radiofrequency pulses robust against respiration in cardiac MRI at 7 Tesla. Magn Reson Med. 2014 Nov 19;.

Naselaris T, Olman CA, Stansbury DE, Ugurbil K, Gallant JL. A voxel-wise encoding model for early visual areas decodes mental images of remembered scenes. Neuroimage. 2014 Oct 29;105C:215-228.

Li X, Wang D, Auerbach EJ, Moeller S, Ugurbil K, Metzger GJ. Theoretical and Experimental Evaluation of Multi-Band EPI for High-Resolution Whole Brain pCASL Imaging. Neuroimage. 2014 Oct 23;.

Chen L, Vu A, Xu J, Moeller S, Ugurbil K, Yacoub E, Feinberg DA. Evaluation of Highly Accelerated Simultaneous Multi-Slice EPI for FMRI. Neuroimage. 2014 Oct 18;104C:452-459.

De Martino F, Moerel M, Ugurbil K, Formisano E, Yacoub E. Less noise, more activation: Multiband acquisition schemes for auditory functional MRI. Magn Reson Med. 2014 Aug 8;.

Griffanti L, Salimi-Khorshidi G, Beckmann CF, Auerbach EJ, Douaud G, Sexton CE, Zsoldos E, Ebmeier KP, Filippini N, Mackay CE, Moeller S, Xu J, Yacoub E, Baselli G, Ugurbil K, Miller KL, Smith SM. ICA-based artefact removal and accelerated fMRI acquisition for improved resting state network imaging. Neuroimage. 2014 Jul 15;95:232-47.

De Martino F, Moerel M, Xu J, van de Moortele PF, Ugurbil K, Goebel R, Yacoub E, Formisano E. High-Resolution Mapping of Myeloarchitecture In Vivo: Localization of Auditory Areas in the Human Brain. Cereb Cortex. 2014 Jul 3;.

Griffanti L, Salimi-Khorshidi G, Beckmann CF, Auerbach EJ, Douaud G, Sexton CE, Zsoldos E, Ebmeier KP, Filippini N, Mackay CE, Moeller S, Xu J, Yacoub E, Baselli G, Ugurbil K, Miller KL, Smith SM. ICA-based artefact removal and accelerated fMRI acquisition for improved resting state network imaging. Neuroimage. 2014 Mar 21;.

Duarte-Carvajalino JM, Lenglet C, Xu J, Yacoub E, Ugurbil K, Moeller S, Carin L, Sapiro G. Estimation of the CSA-ODF using Bayesian compressed sensing of multi-shell HARDI. Magn Reson Med. 2013 Dec 12;.

Xu J, Moeller S, Auerbach EJ, Strupp J, Smith SM, Feinberg DA, Yacoub E, Uğurbil K. Evaluation of slice accelerations using multiband echo planar imaging at 3 T. Neuroimage. 2013 Dec;83:991-1001.

Schmitter S, Bock M, Johst S, Auerbach EJ, Uğurbil K, Van de Moortele PF. Contrast enhancement in TOF cerebral angiography at 7 T using saturation and MT pulses under SAR constraints: Impact of VERSE and sparse pulses. Magn Reson Med. 2011 Dec 2. doi: 10.1002/mrm.23226.

Snyder CJ, Delabarre L, Moeller S, Tian J, Akgun C, Van de Moortele PF, Bolan PJ, Ugurbil K, Vaughan JT, Metzger GJ. Comparison between eight- and sixteen-channel TEM transceive arrays for body imaging at 7 T. Magn Reson Med. 2011 Nov 18. doi: 10.1002/mrm.23070.

Emir UE, Auerbach EJ, Moortele PF, Marjańska M, Uğurbil K, Terpstra M, Tkáč I, Oz G. Regional neurochemical profiles in the human brain measured by (1) H MRS at 7 T using local B(1) shimming. NMR Biomed. 2012 Jan;25(1):152-60. doi: 10.1002/nbm.1727. Epub 2011 Jul 15.

Deelchand DK, Henry PG, Ugurbil K, Marjańska M. Measurement of transverse relaxation times of J-coupled metabolites in the human visual cortex at 4 T. Magn Reson Med. 2011 Jul 11. doi: 10.1002/mrm.23080.

Henry TR, Chupin M, Lehéricy S, Strupp JP, Sikora MA, Sha ZY, Ugurbil K, Van de Moortele PF. Hippocampal sclerosis in temporal lobe epilepsy: findings at 7 T¹. Radiology. 2011 Oct;261(1):199-209. Epub 2011 Jul 11.

From AH, Ugurbil K. Standard magnetic resonance-based measurements of the Pi→ATP rate do not index the rate of oxidative phosphorylation in cardiac and skeletal muscles. Am J Physiol Cell Physiol. 2011 Jul;301(1):C1-11. Epub 2011 Mar 2. Review.

Abosch A, Yacoub E, Ugurbil K, Harel N. An assessment of current brain targets for deep brain stimulation surgery with susceptibility-weighted imaging at 7 tesla. Neurosurgery. 2010 Dec;67(6):1745-56; discussion 1756.

Harel N, Bolan PJ, Turner R, Ugurbil K, Yacoub E. Recent Advances in High-Resolution MR Application and Its Implications for Neurovascular Coupling Research. Front Neuroenergetics. 2010 Sep 27;2:130.

Metzger GJ, van de Moortele PF, Akgun C, Snyder CJ, Moeller S, Strupp J, Andersen P, Shrivastava D, Vaughan T, Ugurbil K, Adriany G. Performance of external and internal coil configurations for prostate investigations at 7 T. Magn Reson Med. 2010 Dec;64(6):1625-39. doi: 10.1002/mrm.22552. Epub 2010 Aug 25.

Goerke U, Garwood M, Ugurbil K. Functional magnetic resonance imaging using RASER. Neuroimage. 2011 Jan 1;54(1):350-60. Epub 2010 Aug 8.

Marjańska M, Iltis I, Shestov AA, Deelchand DK, Nelson C, Uğurbil K, Henry PG. In vivo 13C spectroscopy in the rat brain using hyperpolarized [1-(13)C]pyruvate and [2-(13)C]pyruvate. J Magn Reson. 2010 Oct;206(2):210-8. Epub 2010 Jul 16.

Olman CA, Van de Moortele PF, Schumacher JF, Guy JR, Uğurbil K, Yacoub E. Retinotopic mapping with spin echo BOLD at 7T. Magn Reson Imaging. 2010 Nov;28(9):1258-69. Epub 2010 Jul 24.

Deelchand DK, Van de Moortele PF, Adriany G, Iltis I, Andersen P, Strupp JP, Vaughan JT, Uğurbil K, Henry PG. In vivo 1H NMR spectroscopy of the human brain at 9.4 T: initial results. J Magn Reson. 2010 Sep;206(1):74-80. Epub 2010 Jun 10.

Wu X, Akgün C, Vaughan JT, Andersen P, Strupp J, Uğurbil K, Moortele PF. Adapted RF pulse design for SAR reduction in parallel excitation with experimental verification at 9.4T. J Magn Reson. 2010 May 5.

Wu X, Akgün C, Vaughan JT, Andersen P, Strupp J, Uğurbil K, Van de Moortele PF. Adapted RF pulse design for SAR reduction in parallel excitation with experimental verification at 9.4 T. J Magn Reson. 2010 Jul;205(1):161-70.

Aganj I, Lenglet C, Sapiro G, Yacoub E, Ugurbil K, Harel N. Reconstruction of the orientation distribution function in single- and multiple-shell q-ball imaging within constant solid angle Magn Reson Med. 2010 Aug;64(2):554-66.

Adriany G, Auerbach EJ, Snyder CJ, Gözübüyük A, Moeller S, Ritter J, Van de Moortele PF, Vaughan T, Uğurbil K. A 32-channel lattice transmission line array for parallel transmit and receive MRI at 7 tesla. Magn Reson Med. 2010 Jun;63(6):1478-85.

Rao R, Ennis K, Long JD, Ugurbil K, Gruetter R, Tkac I. Neurochemical changes in the developing rat hippocampus during prolonged hypoglycemia. J Neurochem. 2010 Aug;114(3):728-38. Epub 2010 May 6.

Moeller S, Yacoub E, Olman CA, Auerbach E, Strupp J, Harel N, Uğurbil K. Multiband multislice GE-EPI at 7 tesla, with 16-fold acceleration using partial parallel imaging with application to high spatial and temporal whole-brain fMRI. Magn Reson Med. 2010 May;63(5):1144-53.

Wu X, Vaughan JT, Uğurbil K, Van de Moortele PF. Parallel excitation in the human brain at 9.4 T counteracting k-space errors with RF pulse design. Magn Reson Med. 2010 Feb;63(2):524-9.


Former Graduate Students:

Cheryl Olman (Ph.D. 2003, Neuroscience, University of Minnesota).

Kamil Ugurbil