Using touchscreen behavioral testing and a suite of molecular and genetic techniques in mouse models, we work to uncover the molecular mechanisms in mesocorticolimbic regions that permit mice, and us, to learn new goal-directed behaviors, make decisions and choices between options, maintain motivation, and exert control over impulsive and habitual actions. Because these abilities are often altered in neuropsychiatric diseases, such as in neurodevelopmental disorders including autism and ADHD, understanding the molecular regulators of neuronal ensembles mediating these abilities may reveal what makes these brains unique and identify new therapeutic avenues. Critically, because neurodevelopmental disorders are significantly more prevalent in males, we are working to uncover potential molecular and circuit mechanisms of male vulnerability and/or female resilience to genotypes associated with these disorders.
(Click here for a comprehensive list of recent publications)
Nicola M. Grissom, Sarah E. McKee, Hannah Schoch, Nicole Bowman, Robbert Havekes, W. Timothy O’Brien, Elena Mahrt, Steven Siegel, Kathryn Commons, Christine Portfors, Thomas Nickl-Jockschat, Teresa M. Reyes, Ted Abel. Male-specific deficits in natural reward learning in a mouse model of neurodevelopmental disorders. Molecular Psychiatry 2017
NM Grissom, CT Herdt, J Desilets, J Lidsky-Everson, TM Reyes. Dissociable deficits of executive function caused by gestational adversity are linked to specific transcriptional changes in the prefrontal cortex. Neuropsychopharmacology 2015
Nicola M Grissom, Randolph Lyde, Lori Christ, Isaac E Sasson, JesseLea Carlin, Alexa P Vitins, Rebecca A Simmons, Teresa M Reyes. Obesity at conception programs the opioid system in the offspring brain. Neuropsychopharmacology 2014